Bioactive Small Molecules
Cayman Chemical ANTIBODY Erteberel 5mg
An ERβ agonist; selective for ERβ over ERα in reporter assays using PC3 cells expressing the human receptors (EC50s = 0.66 and 19.4 nM, respectively); induces apoptosis and cell cycle arrest at the G2/M phase in U87MG and U251 cells at 5 µM; enhances cisplatin-, lomustine-, or bleomycin-induced cytotoxicity in U251 cells at 1 µM; reduces tumor growth in a U251 orthotopic model of glioblastoma in ovariectomized mice at 5 mg/kg; decreases prostate weight in a mouse model of BPH at 0.01, 0.025, and 0.05 mg/kg
Medchemexpress LLC AMP-Deoxynojirimycin 50mg | 216758-20-2 | 397.55 | C22H39NO5 | 50 MG
AMP-Deoxynojirimycin (AMP-DNM) is a small-molecule inhibitor of ceramide glucosyltransferase and non-lysosomal glucosylceramidase (GCase2). It is used as a biochemical tool to inhibit glucosylceramide (GlcCer) biosynthesis in cellular and animal studies.
- Inhibits ceramide glucosyltransferase and GCase2, blocking GlcCer biosynthesis.
- Suitable as a research tool for studying glycosphingolipid metabolism and related pathways.
- Provided as a solid powder for preparation of assay solutions.
- Available in multiple pack sizes, including 50 mg.
- Reported purity ~98% (see manufacturer documentation).
Medchemexpress LLC CYM-5478 | 870762-83-7 | 99.9% | 388.38 | 25 MG
CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. It protects neural-derived cell lines against Cisplatin toxicity.
- Potent and highly selective S1P2 agonist
- Protects neural-derived cell lines against Cisplatin toxicity
- Attenuates Cisplatin-induced caspase 3/7 activity
- Attenuates increase of ROS in C6 cells exposed to Cisplatin
- Protects against Cisplatin-mediated ototoxicity
- Protects against loss of hair cell viability in a zebrafish model
Medchemexpress LLC AZD5904 | 618913-30-7 | 99.9% | 252.29 | 25 MG
AZD5904 is a selective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It demonstrates 10 to 19-fold selectivity compared to closely related lactoperoxidase and thyroid peroxidase, and >70-fold selectivity to a broad panel of other enzymes, ion channels, and receptors.
- Selective and irreversible inhibitor of human Myeloperoxidase (MPO)
- IC50 of 140 nM
- Similar potency in mouse and rat
- Highly selective compared to lactoperoxidase and thyroid peroxidase
- Highly selective compared to other enzymes, ion channels, and receptors
Medchemexpress LLC Florfenicol (standard) | 73231-34-2 | 99.72% | 50 MG
Florfenicol (Standard) is the analytical standard of Florfenicol. It is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions. This analytical standard is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
- Intended for research and analytical applications
- Broad-spectrum antibacterial antibiotic
- Anti-inflammatory, pro apoptotic, and immunomodulatory functions
- Suitable for HPLC, GC and MS applications
Cayman Chemical L-MoseshydrochlorIde 5mg
A PCAF bromodomain inhibitor (Kd = 126 nM); selective for PCAF over GCN5 (Kd = 600 nM); >4,500-fold selective for PCAF over BRD4; displaces the PCAF bromodomain from histone H3.3 in a nanoBRET target engagement assay at 5 μM
Cayman Chemical 3fluoro MT45hydrochLRIde 5mg
An analytical reference standard categorized as an opioid; intended for research and forensic applications
Cayman Chemical BenzoylaconIn 5mg
An aconitine-type diterpenoid alkaloid that has been found in Aconitum species; increases protein levels of the efflux transporters P-glycoprotein, MRP2, and BCRP in LS174T cells in a concentration-dependent manner; increases the protein levels of P-glycoprotein in Caco-2 cells and the PXR in both Caco-2 and LS174T cells at 50 μM; reduces the cytotoxic effects of the P-glycoprotein substrates vincristine and doxorubicin in Caco-2 cells at 50 μM; increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice at 0.6 mg/kg; increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.)
Cayman Chemical ANTIBODY GAT229 10mg
An allosteric modulator of the CB1 receptor; the S-(–) enantiomer of GAT211; enhances the binding of CP 55,940 to CHO cells expressing hCB1 by 130% at 1 μM; enhances the activity of 2-AG, AEA, and CP 55,940 in arrestin2, as well as ERK1/2 and PLCβ3 phosphorylation, assays to HEK293 cells expressing hCB1; enhances depolarization-induced suppression of excitation but does not inhibit excitatory postsynaptic currents in murine autaptic hippocampal neurons at 1 μM; reduces intraocular pressure by 5.8 and 7.7 mm Hg after 6 and 12 hours, respectively, in a nee transgenic mouse model of ocular hypertension at 0.2%, topical
Medchemexpress LLC PA452 | 457657-34-0 | ≥99.0% | 439.59 | 1 MG
PA452 is a specific antagonist of the retinoic X receptor (RXR) that inhibits the effect of Retinoic acid (RA) on Th1/Th2 development. In vitro, PA452 inhibits Troglitazone (TZ)-induced CK13 expression and inhibits RXR in normal human urothelial (NHU) cells.
- Specific antagonist of the retinoic X receptor (RXR)
- Inhibits the effect of retinoic acid (RA) on Th1/Th2 development
- Inhibits Troglitazone (TZ)-induced CK13 expression
- Inhibits RXR in normal human urothelial (NHU) cells
Cayman Chemical ANTIBODY FM-381 10mg
A potent JAK3 inhibitor (IC50 = 127 pM); 400-, 2,700-, and 3,600-fold selective for JAK3 over JAK1, JAK2, and TYK3 and only inhibits 11 kinases in a panel of 410 kinases at 500 nM; blocks JAK3-dependent STAT5 phosphorylation but not JAK3-independent STAT3 signaling in IL-2- and IL-6-stimulated T cells, respectively, at 1 μM
Medchemexpress LLC Transcription Factor EB Antibody (YA3266) | 50 UL
The Transcription Factor EB Antibody (YA3266) is a rabbit-derived antibody designed to react with human proteins. It is supplied as a liquid formulation suitable for various laboratory applications.
- Host: Rabbit
- Reactivity: Human
- Clonality: YA3266
- Molecular weight: Predicted band size 53 kDa; Observed band size 65-70 kDa
- Concentration: 0.3 mg/mL
- Non-conjugated
- Applications include WB, IHC-F, IHC-P, ICC/IF, and IP
- Formulated in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Store at -20°C for 1 year
- Avoid repeated freeze / thaw cycles
- Ships with blue ice
Cayman Chemical ANTIBODY BB-F-Yn 500ug
A clickable PAD inhibitor; inhibits PAD1-4 (kinact/KI values of 900, 1,200, 3,400, and 3,750 M-1min-1, respectively); has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA reporters or biotin capture reagents
![Medchemexpress LLC N-(3-chlorophenyl)-8-[[1-(4-methyl-2-nitrophenyl)-1H-1,2,3-triazol-4-yl]methoxy]-2-quinazolinamine | 2587177-94-2 | 98.3% | C24H18ClN7O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261055.png-250.jpg)
Medchemexpress LLC N-(3-chlorophenyl)-8-[[1-(4-methyl-2-nitrophenyl)-1H-1,2,3-triazol-4-yl]methoxy]-2-quinazolinamine | 2587177-94-2 | 98.3% | C24H18ClN7O3 | 10MG
DB18 is a small-molecule inhibitor of CDC2-like kinases (CLKs) with potent, selective activity and reported anti-tumor effects. The compound exhibits low-nanomolar inhibition of CLK isoforms and is supplied as a high-purity solid for research applications.
- Potent, selective inhibitor of CDC2-like kinases (CLKs).
- Low-nanomolar IC50 (10-30 nM) for CLK1, CLK2, and CLK4.
- Demonstrated anti-tumor activity in preclinical studies.
- High purity suitable for biochemical assays.
- Soluble in DMSO at 50 mg/mL with ultrasonic warming.
- Stable when stored under recommended conditions.
Medchemexpress LLC Dorzagliatin | 1191995-00-2 | 99.89% | 462.93 | 50 MG
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in type 2 diabetes. It is for research use only and not sold to patients.
- Dual-acting glucokinase (GK) activator
- Improves glycaemic control and pancreatic β-cell function in type 2 diabetes